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Limits: Publication Date from 2003/10/01 to
2005/02/01

Summary Brief Abstract Citation ASN.1
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1:
Circulation. 2004 Jun 1;109(21):2566-71. Epub 2004 May 10.

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C-reactive protein
promotes monocyte chemoattractant protein-1--mediated chemotaxis through
upregulating CC chemokine receptor 2 expression in human
monocytes.

Han KH, Hong KH, Park JH, Ko J, Kang DH,
Choi KJ, Hong MK, Park SW, Park SJ.

Asan Medical Center,
University of Ulsan College of Medicine, Seoul, South Korea.
[email-masked]

BACKGROUND: Inflammation plays a crucial
role in atherosclerosis. An elevated serum C-reactive protein (CRP)
level is a strong marker for future atherosclerotic cardiovascular
diseases. In addition, recent data suggest that CRP may directly promote
atherogenesis. In this study, we investigated whether CRP can directly
activate human circulating monocytes. METHODS AND RESULTS: Incubation of
THP-1 monocytes with CRP (10 microg/mL) increased CC chemokine receptor
2 (CCR2) expression at both the protein and transcript levels, which in
turn enhanced chemotaxis mediated by monocyte chemoattractant protein-1
(MCP-1) up to 2-fold. The CRP-induced upregulation of CCR2 expression
involved binding of CRP to the FcgammaR, most notably FcgammaRI, and
phospholipase D1 activation. Serum high-sensitivity CRP levels in 52
normocholesterolemic human subjects were positively correlated with CCR2
surface expression on circulating monocytes (r=0.62, P<0.001) and
MCP-1-mediated monocyte chemotaxis (r=0.53, P<0.001). CONCLUSIONS:
Elevated blood CRP levels may promote accumulation of monocytes in the
atherogenic arterial wall by increasing chemotactic activities of
monocytes in response to MCP-1.

PMID: 15136507 [PubMed - indexed
for MEDLINE]

Summary Brief Abstract Citation ASN.1
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